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Research

Hydroxocobalamin — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Hydroxocobalamin is a cyanide antidote: among 69 smoke-inhalation victims with suspected cyanide poisoning given 5 g intravenously, 72% survived, 67% of those with confirmed poisoning, with no serious adverse events attributed to it. · pmid:17481777

In healthy heavy smokers, 5 g of intravenous hydroxocobalamin lowered whole-blood cyanide by 59% and turned skin and urine temporarily red, with a transient rise in blood pressure. · pmid:8492341

Identity

PubChem CID 44475014: Hydroxocobalamin, C62H89CoN13O15P, 1346.4 g/mol. · pubchem:44475014

CAS registry number 13422-51-0. · pubchem:44475014

Where the evidence actually sits

Emerging100%

Proportion of the 2 claims about Hydroxocobalamin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. (1993) · emergingProspective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. (2007) · emerging19932007

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Hydroxocobalamin yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. · pmid 17481777 · 2007
    • Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. · pmid 8492341 · 1993
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.