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Research

IGF-1 DES — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Des(1-3)IGF-I is a truncated variant of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu; it has been isolated from bovine colostrum, human brain and porcine uterus. · pmid:8930132

Mechanism

It is generally about ten times more potent than IGF-I on cultured cells because it binds IGF-binding proteins far less, a consequence of losing the glutamate at position 3. · pmid:8930132

History

A protease able to generate it from IGF-I was found in rat serum and tissues, and its activity rose after hypophysectomy and fell with growth hormone treatment. · pmid:7561610

Identity

No public registry record is shown for this page: PubChem gave no record that proves it is this substance.

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about IGF-1 DES standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action. (1995) · preclinicalDes(1-3)IGF-I: a truncated form of insulin-like growth factor-I. (1996) · preclinical19951996

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for IGF-1 DES yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action. · pmid 7561610 · 1995
    • Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I. · pmid 8930132 · 1996

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.