Research
Ipamorelin — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Ipamorelin is the pentapeptide Aib-His-D-2-Nal-D-Phe-Lys-NH2, described as the first selective growth hormone secretagogue; it releases growth hormone through a GHRP-like receptor with potency and efficacy similar to GHRP-6. · pmid:9849822
History
In a phase 2 randomized trial of 114 bowel-resection patients with postoperative ileus, it was well tolerated but did not differ significantly from placebo in time to a tolerated meal. · pmid:25331030
Identity
PubChem CID 9831659: Ipamorelin, C38H49N9O5, 711.9 g/mol. · pubchem:9831659
CAS registry number 170851-70-4. · pubchem:9831659
IUPAC name: (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide. · pubchem:9831659
Where the evidence actually sits
Proportion of the 2 claims about Ipamorelin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Ipamorelin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
- Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. · pmid 25331030 · 2014
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Ipamorelin, the first selective growth hormone secretagogue. · pmid 9849822 · 1998
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.