Research
Kisspeptin-10 — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity. · pmid:21632807
Classification
It is a decapeptide derived from the 145-amino-acid primary translation product of the KiSS-1 gene, which also yields kisspeptins of 13, 14 and 54 residues. · pmid:15020672
Mechanism
It was identified in medium from first-trimester human trophoblast and acts as a physiological inhibitor of trophoblast invasion. · pmid:15020672
History
In healthy men an intravenous bolus produced a rapid, dose-dependent rise in luteinizing hormone, and infusion increased LH pulse frequency. · pmid:21632807
Identity
PubChem CID 25240297: Kisspeptin-10, C63H83N17O14, 1302.4 g/mol. · pubchem:25240297
CAS registry number 374675-21-5. · pubchem:25240297
Where the evidence actually sits
Proportion of the 2 claims about Kisspeptin-10 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Kisspeptin-10 yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
- Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. · pmid 21632807 · 2011
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. · pmid 15020672 · 2004
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.