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Research

L-Arginine HCl — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Arginine is widely used in protein production as an aggregation suppressor rather than a protein stabilizer, acting by weakening protein-protein interactions. · pmid:16522173

Mechanism

It barely changed protein melting temperature but increased the reversibility of thermal melting and reduced aggregation under thermal stress. · pmid:12705899

Identity

PubChem CID 66250: L-Arginine, monohydrochloride, C6H15ClN4O2, 210.66 g/mol. · pubchem:66250

CAS registry number 1119-34-2. · pubchem:66250

IUPAC name: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;hydrochloride. · pubchem:66250

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about L-Arginine HCl standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation. (2003) · preclinicalReview: Why is arginine effective in suppressing aggregation? (2005) · preclinical20032005

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Arginine HCl yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation. · pmid 12705899 · 2003
    • Review: Why is arginine effective in suppressing aggregation? · pmid 16522173 · 2005

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.