L-Carnitine — living evidence map

Summary

A meta-analysis of 49 randomized trials in adults on maintenance hemodialysis found that L-carnitine lowered LDL cholesterol and C-reactive protein, but did not confirm earlier findings on hemoglobin or erythropoietin dose. · pmid:24368434

A systematic review of 11 studies in healthy people taking oral L-carnitine for 12 to 24 weeks found that it raised muscle carnitine when taken with carbohydrate, and raised fasting plasma trimethylamine-N-oxide (TMAO). · pmid:32958033

Identity

PubChem CID 10917: (-)-Carnitine, C7H15NO3, 161.20 g/mol. · pubchem:10917

CAS registry number 541-15-1. · pubchem:10917

IUPAC name: (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate. · pubchem:10917

Where the evidence actually sits

Proportion of the 2 claims about L-Carnitine standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Carnitine yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • L-Carnitine supplementation for adults with end-stage kidney disease requiring maintenance hemodialysis: a systematic review and meta-analysis. · pmid 24368434 · 2014
3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • The bright and the dark sides of L-carnitine supplementation: a systematic review. · pmid 32958033 · 2020
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.