Research
L-Proline — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Proline, an osmolyte, prevented aggregation during the refolding of lysozyme where other osmolytes tested did not, apparently by trapping folding intermediates in aggregation-insensitive states. · pmid:10716186
Identity
PubChem CID 145742: L-Proline, C5H9NO2, 115.13 g/mol. · pubchem:145742
CAS registry number 147-85-3. · pubchem:145742
IUPAC name: (2S)-pyrrolidine-2-carboxylic acid. · pubchem:145742
Where the evidence actually sits
Proportion of the 1 claim about L-Proline standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Proline yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Proline inhibits aggregation during protein refolding. · pmid 10716186 · 2000
1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.