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Research

Magnesium sulfate heptahydrate — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In the Magpie trial of 10,141 women with pre-eclampsia in 33 countries, magnesium sulphate halved the risk of eclampsia compared with placebo (58% lower) and probably reduced maternal death. · pmid:12057549

A Cochrane review of five trials (6,145 babies) found that magnesium sulphate given to women at risk of preterm birth reduced cerebral palsy in their children (relative risk 0.68). · pmid:19160238

Identity

PubChem CID 24843: Magnesium Sulfate Heptahydrate, H14MgO11S, 246.48 g/mol. · pubchem:24843

CAS registry number 10034-99-8. · pubchem:24843

IUPAC name: magnesium;sulfate;heptahydrate. · pubchem:24843

Where the evidence actually sits

Established100%

Proportion of the 2 claims about Magnesium sulfate heptahydrate standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. (2002) · establishedMagnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. (2009) · established20022009

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Magnesium sulfate heptahydrate yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. · pmid 12057549 · 2002
    • Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. · pmid 19160238 · 2009
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.