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Research

Manganese chloride tetrahydrate — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Manganese is an essential micronutrient required by enzymes such as arginase and glutamine synthetase, but it is toxic in excess. · pmid:25974698

A review of adults on parenteral nutrition found manganese toxicity after as little as 15 days, with doses in commercial trace-element products often exceeding guideline amounts. · pmid:34753157

Identity

PubChem CID 643989: Manganese Chloride Tetrahydrate, Cl2H8MnO4, 197.90 g/mol. · pubchem:643989

CAS registry number 13446-34-9. · pubchem:643989

IUPAC name: dichloromanganese;tetrahydrate. · pubchem:643989

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Manganese chloride tetrahydrate standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Manganese Is Essential for Neuronal Health. (2015) · establishedManganese Toxicity Associated With Total Parenteral Nutrition: A Review. (2021) · emerging20152021

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Manganese chloride tetrahydrate yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Manganese Is Essential for Neuronal Health. · pmid 25974698 · 2015
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Manganese Toxicity Associated With Total Parenteral Nutrition: A Review. · pmid 34753157 · 2021
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.