Melanotan I — living evidence map

Summary

Afamelanotide is an analogue of alpha-melanocyte-stimulating hormone, studied as a subcutaneous implant. · pmid:26132941

History

In two randomized placebo-controlled trials in erythropoietic protoporphyria, a severe light-sensitivity disorder, it was evaluated for pain-free time in direct sunlight and quality of life. · pmid:26132941

A long-term study of 115 patients treated with 1,023 implants over up to eight years at two porphyria centres recorded continued use and quality-of-life improvements. · pmid:25494545

Identity

PubChem CID 16197727: Afamelanotide, C78H111N21O19, 1646.8 g/mol. · pubchem:16197727

CAS registry number 75921-69-6. · pubchem:16197727

Where the evidence actually sits

Proportion of the 2 claims about Melanotan I standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Melanotan I yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Afamelanotide for Erythropoietic Protoporphyria. · pmid 26132941 · 2015
3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria. · pmid 25494545 · 2015
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.