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Research

Melanotan II — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Melanotan II is a lactam-bridged cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone, Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-MSH(4-10)-NH2, with superpotent melanotropic activity in vitro. · pmid:8637402

History

In a pilot phase I study in three men it increased skin pigmentation, and spontaneous erections and a stretching and yawning complex followed doses; mild nausea was common. · pmid:8637402

In a double-blind crossover study of 20 men with erectile dysfunction, Melanotan II, a non-selective melanocortin receptor agonist, led to erections in 17 without sexual stimulation; nausea and yawning were frequent side effects. · pmid:11035391

Identity

PubChem CID 92432: melanotan-II, C50H69N15O9, 1024.2 g/mol. · pubchem:92432

CAS registry number 121062-08-6. · pubchem:92432

IUPAC name: (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide. · pubchem:92432

Where the evidence actually sits

Emerging100%

Proportion of the 2 claims about Melanotan II standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. (1996) · emergingMelanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. (2000) · emerging19962000

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Melanotan II yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. · pmid 11035391 · 2000
    • Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. · pmid 8637402 · 1996
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.