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Research

Niacinamide — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Nicotinic acid and nicotinamide together make up niacin, the NAD+ precursor vitamin; less than 20 mg a day (or dietary tryptophan) meets baseline NAD+ needs. · pmid:18429699

In a US Veterans Affairs cohort of about 33,800 matched patients, oral nicotinamide 500 mg twice daily was associated with a 14% lower risk of new skin cancers, rising to 54% when started after a first skin cancer. · pmid:40960808

Identity

PubChem CID 936: Nicotinamide, C6H6N2O, 122.12 g/mol. · pubchem:936

CAS registry number 98-92-0. · pubchem:936

IUPAC name: pyridine-3-carboxamide. · pubchem:936

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Niacinamide standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. (2008) · establishedNicotinamide for Skin Cancer Chemoprevention. (2025) · emerging20082025

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Niacinamide yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. · pmid 18429699 · 2008
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Nicotinamide for Skin Cancer Chemoprevention. · pmid 40960808 · 2025
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.