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Research

Nicotinic acid — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Nicotinic acid is one of the two forms of niacin, the NAD+ precursor vitamin; baseline NAD+ needs are met with less than 20 mg a day. · pmid:18429699

A meta-analysis of 39 trials with 117,411 patients found that niacin raised HDL cholesterol but did not lower all-cause mortality, coronary deaths or strokes, and reduced non-fatal heart attacks only in studies without statin treatment. · pmid:25038074

Identity

PubChem CID 938: Nicotinic Acid, C6H5NO2, 123.11 g/mol. · pubchem:938

CAS registry number 59-67-6. · pubchem:938

IUPAC name: pyridine-3-carboxylic acid. · pubchem:938

Where the evidence actually sits

Established100%

Proportion of the 2 claims about Nicotinic acid standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. (2008) · establishedEffect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients. (2014) · established20082014

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Nicotinic acid yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. · pmid 18429699 · 2008
    • Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients. · pmid 25038074 · 2014
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.