Research
Pentosan Polysulfate Sodium — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Pentosan polysulfate is a sulfated oligosaccharide, not a peptide. · pmid:2465736
History
In a 1990 double-blind multicentre trial in interstitial cystitis, overall improvement above 25% was reported by 28% of 110 patients on pentosan polysulfate sodium against 13% on placebo. · pmid:1693797
Chronic exposure has been associated with a distinctive pigmentary maculopathy; the first case series described six patients with a median exposure of 186 months. · pmid:29801663
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Proportion of the 3 claims about Pentosan Polysulfate Sodium standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Pentosan Polysulfate Sodium yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
- Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. · pmid 1693797 · 1990
- Observational evidence · resolved human data at the emerging tier: thin, or contested
- Pigmentary Maculopathy Associated with Chronic Exposure to Pentosan Polysulfate Sodium. · pmid 29801663 · 2018
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. · pmid 2465736 · 1988
3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.