Phytonadione (Vitamin K1) — living evidence map

Summary

Newborns are at risk of vitamin K deficiency bleeding in their first six months; under Switzerland's oral vitamin K prophylaxis, nine cases occurred among 505,708 births (2018-2024), all in exclusively breast-fed infants with risk factors such as refused prophylaxis. · pmid:41545738

Intravenous phytonadione (vitamin K1) caused anaphylaxis in about 3 per 10,000 doses at one academic centre, a reaction attributed to its solubilising vehicle, polyethoxylated castor oil. · pmid:12392385

Identity

PubChem CID 5284607: Phylloquinone, C31H46O2, 450.7 g/mol. · pubchem:5284607

CAS registry number 84-80-0. · pubchem:5284607

IUPAC name: 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione. · pubchem:5284607

Where the evidence actually sits

Proportion of the 2 claims about Phytonadione (Vitamin K1) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Phytonadione (Vitamin K1) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Oral neonatal vitamin K deficiency bleeding prophylaxis in Switzerland (2018-2024), still valid guidelines for healthy infants. · pmid 41545738 · 2026
3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. · pmid 12392385 · 2002
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.