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Research

Polydatin — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Polydatin (piceid, 3,4',5-trihydroxystilbene-3-beta-D-glucoside) is a stilbene glucoside isolated from Polygonum cuspidatum and also found in grapes, peanuts, hop cones, red wine and cocoa products; it is not a peptide. · pmid:23862567

History

A review of research since 1990, drawing on English- and Chinese-language databases including CNKI, found studies centred on cardiovascular effects, neuroprotection, anti-inflammatory and antioxidant actions, and liver and lung protection. · pmid:23862567

Identity

PubChem CID 5281718: Polydatin, C20H22O8, 390.4 g/mol. · pubchem:5281718

CAS registry number 27208-80-6, 65914-17-2. · pubchem:5281718

IUPAC name: (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol. · pubchem:5281718

Where the evidence actually sits

Preclinical only100%

Proportion of the 1 claim about Polydatin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Polydatin: a review of pharmacology and pharmacokinetics. (2013) · preclinical20132013

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Polydatin yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Polydatin: a review of pharmacology and pharmacokinetics. · pmid 23862567 · 2013

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.