Research
PTD-DBM — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
PTD-DBM (protein transduction domain fused to a Dishevelled-binding motif) is a competitor peptide that blocks the interaction of CXXC5 with Dishevelled, a negative feedback brake on Wnt/beta-catenin signalling. · pmid:26056233
Mechanism
It activated beta-catenin and collagen production in vitro, and mice lacking CXXC5 showed accelerated cutaneous wound healing. · pmid:26056233
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Proportion of the 1 claim about PTD-DBM standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for PTD-DBM yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. · pmid 26056233 · 2015
1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.