PepJunkie Home of the Peptonauts
More
HomeThe PulseAtlasDiscussHunter-GathererResearchProfileSearch

Research

Pyridoxal 5'-phosphate — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Pyridoxal 5'-phosphate (PLP) is the active coenzyme form of vitamin B6; PLP-dependent enzymes catalyze an unrivalled diversity of reactions. · pmid:15189147

In PNPO deficiency, an ultrarare inherited epileptic encephalopathy, a systematic review of 49 PLP-treated patients found seizure response in 77.6% and better survival than in untreated siblings; liver toxicity occurred in 20.4%, possibly linked to high doses. · pmid:40751583

Identity

PubChem CID 1051: Pyridoxal 5'-phosphate, C8H10NO6P, 247.14 g/mol. · pubchem:1051

CAS registry number 54-47-7. · pubchem:1051

IUPAC name: (4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate. · pubchem:1051

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Pyridoxal 5'-phosphate standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations. (2004) · establishedEffectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review. (2025) · emerging20042025

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Pyridoxal 5'-phosphate yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations. · pmid 15189147 · 2004
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Effectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review. · pmid 40751583 · 2025
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.