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Research

Sodium selenite — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

In the SISPCT trial of 1,089 patients with severe sepsis or septic shock, high-dose intravenous sodium selenite did not lower 28-day mortality (28.3% against 25.5% on placebo). · pmid:27428731

An earlier trial of intravenous sodium selenite in 238 patients with sepsis found 39.7% mortality against 50.0% on placebo, a difference that was not significant in the intention-to-treat analysis. · pmid:17095947

In a phase I trial in 34 patients with therapy-resistant cancers, the maximum tolerated dose of intravenous sodium selenite was 10.2 mg/m2, with fatigue, nausea and cramps the commonest adverse events. · pmid:26102212

Identity

PubChem CID 24934: Sodium Selenite, Na2O3Se, 172.95 g/mol. · pubchem:24934

CAS registry number 10102-18-8. · pubchem:24934

IUPAC name: disodium;selenite. · pubchem:24934

Where the evidence actually sits

Established33%
Emerging67%

Proportion of the 3 claims about Sodium selenite standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. (2007) · emergingPharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study. (2015) · emergingEffect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. (2016) · established20072016

3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Sodium selenite yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. · pmid 27428731 · 2016
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. · pmid 17095947 · 2007
    • Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study. · pmid 26102212 · 2015
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.