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Research

Sodium Succinate — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Succinate buffer can crystallize in frozen solutions, shifting the pH of the freeze-concentrate; at an initial pH of 6.0, glycine and mannitol stayed amorphous and inhibited that crystallization. · pmid:20927571

Identity

PubChem CID 3083938: Sodium Succinate Hexahydrate, C4H16Na2O10, 270.14 g/mol. · pubchem:3083938

CAS registry number 6106-21-4. · pubchem:3083938

IUPAC name: disodium;butanedioate;hexahydrate. · pubchem:3083938

Where the evidence actually sits

Preclinical only100%

Proportion of the 1 claim about Sodium Succinate standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

The effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions. (2011) · preclinical20112011

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Sodium Succinate yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • The effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions. · pmid 20927571 · 2011

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.