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Research

Thiamine hydrochloride — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Thiamine is an essential micronutrient central to energy metabolism; populations relying on milled or washed staple grains are at risk of deficiency, which contributes to infant mortality through infantile beriberi. · pmid:30151974

In the VICTAS trial of 501 patients with sepsis, intravenous vitamin C, thiamine and hydrocortisone did not increase ventilator- and vasopressor-free days compared with placebo; the trial stopped early for administrative reasons. · pmid:33620405

Identity

PubChem CID 6202: Thiamine Hydrochloride, C12H18Cl2N4OS, 337.3 g/mol. · pubchem:6202

CAS registry number 67-03-8. · pubchem:6202

IUPAC name: 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride. · pubchem:6202

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Thiamine hydrochloride standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. (2018) · establishedEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. (2021) · emerging20182021

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thiamine hydrochloride yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. · pmid 30151974 · 2018
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. · pmid 33620405 · 2021
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.