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Thymosin Alpha-1 — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Thymosin alpha 1 is a heat-stable, highly acidic polypeptide of 28 amino acids, isolated from calf thymus as one of the peptides of thymosin fraction 5. · pmid:265536

Mechanism

It induced functional maturation and interleukin-12 production in fungus-pulsed dendritic cells through Toll-like receptor signalling, and protected transplanted mice from aspergillosis. · pmid:14982877

Identity

PubChem CID 16130571: Thymalfasin, C129H215N33O55, 3108.3 g/mol. · pubchem:16130571

CAS registry number 62304-98-7. · pubchem:16130571

Where the evidence actually sits

Established50%
Preclinical only50%

Proportion of the 2 claims about Thymosin Alpha-1 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. (1977) · establishedThymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. (2004) · preclinical19772004

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymosin Alpha-1 yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. · pmid 265536 · 1977
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. · pmid 14982877 · 2004

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.