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Research

Thymosin Beta-4 — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Thymosin beta 4 is an acidic, heat-stable peptide of about 5 kDa, first isolated from calf thymus, identical to Fx, the peptide that holds much of the unpolymerized actin in human platelets. · pmid:1999398

Mechanism

It forms a 1:1 complex with actin monomers and inhibits their polymerization. · pmid:1999398

History

After coronary artery ligation in mice, it activated integrin-linked kinase and Akt, enhanced early cardiomyocyte survival and improved cardiac function. · pmid:15565145

Identity

PubChem CID 16132341: Timbetasin, C212H350N56O78S, 4963 g/mol. · pubchem:16132341

CAS registry number 77591-33-4. · pubchem:16132341

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about Thymosin Beta-4 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. (1991) · preclinicalThymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. (2004) · preclinical19912004

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymosin Beta-4 yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. · pmid 15565145 · 2004
    • Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. · pmid 1999398 · 1991

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.