Research
Thymosin Fraction 5 (TF5) — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Mass spectrometry of a sample stored for 37 years found over 100 polypeptide masses, including thymosin beta 4, truncated forms of ubiquitin, prothymosin alpha and thymosins, and a previously unrecognised protein. · pmid:30063862
Classification
Thymosin fraction 5 is a partially purified extract of calf thymus, a mixture of polypeptides from which thymosin alpha 1 and thymosin beta 4 were isolated. · pmid:2954929
Mechanism
In human mixed lymphocyte reactions, thymosin alpha 1 from fraction 5 enhanced proliferation, while thymosin beta 4 activated suppressor T cells to damp it. · pmid:2954929
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Proportion of the 2 claims about Thymosin Fraction 5 (TF5) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Thymosin Fraction 5 (TF5) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
nothing resolved on this rung
- Observational evidence · resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
- Immunoregulatory effects of fraction 5 thymus peptides. I. Thymosin alpha 1 enhances while thymosin beta 4 suppresses the human autologous and allogeneic mixed lymphocyte reaction. · pmid 2954929 · 1987
- Thymosin fraction 5 re-evaluated after 35 years by high-resolution mass spectrometry. · pmid 30063862 · 2018
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.