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Research

Triptorelin — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Triptorelin is a gonadotropin-releasing hormone analogue; in 66 children treated with slow-release triptorelin for central precocious puberty, final height matched the genetic target, and girls gained 4.8 cm over their predicted height. · pmid:10372696

Classification

Triptorelin has been tested as temporary ovarian suppression during chemotherapy to prevent early menopause in premenopausal women with breast cancer (the PROMISE-GIM6 phase 3 trial). · pmid:21771987

Identity

PubChem CID 25074470: Triptorelin, C64H82N18O13, 1311.4 g/mol. · pubchem:25074470

CAS registry number 57773-63-4. · pubchem:25074470

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Triptorelin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment. French study group of Decapeptyl in Precocious Puberty. (1999) · emergingEffect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial. (2011) · established19992011

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Triptorelin yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial. · pmid 21771987 · 2011
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment. French study group of Decapeptyl in Precocious Puberty. · pmid 10372696 · 1999
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.