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Research

Ubidecarenone (injectable CoQ10) — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Coenzyme Q10 (ubidecarenone) is a cofactor for mitochondrial energy production and an antioxidant; in the Q-SYMBIO trial of 420 patients with moderate to severe heart failure, two years of oral coenzyme Q10 reduced major adverse cardiovascular events (15% against 26% on placebo). · pmid:25282031

A meta-analysis of six randomized trials in 302 statin-treated patients found no significant effect of coenzyme Q10 on muscle pain or creatine kinase. · pmid:25440725

Identity

PubChem CID 5281915: Coenzyme Q10, C59H90O4, 863.3 g/mol. · pubchem:5281915

CAS registry number 303-98-0. · pubchem:5281915

IUPAC name: 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione. · pubchem:5281915

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Ubidecarenone (injectable CoQ10) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014) · emergingEffects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. (2015) · established20142015

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Ubidecarenone (injectable CoQ10) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. · pmid 25440725 · 2015
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. · pmid 25282031 · 2014
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.