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Research

Vilon — living evidence map

The Atlas page holds the claims; this is how its evidence evolved.

Summary

Vilon is the dipeptide Lys-Glu; in mice given the carcinogen 1,2-dimethylhydrazine, tumours developed in 14.3% of treated animals against 60% of controls. · pmid:16308980

History

Given monthly to female CBA mice from six months of age, the dipeptide Lys-Glu increased physical activity and lowered the incidence of spontaneous lung adenomas. · pmid:11163623

Identity

PubChem CID 7010502: Lysylglutamic acid, C11H21N3O5, 275.30 g/mol. · pubchem:7010502

CAS registry number 45234-02-4. · pubchem:7010502

IUPAC name: (2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid. · pubchem:7010502

Where the evidence actually sits

Preclinical only100%

Proportion of the 2 claims about Vilon standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. (2001) · preclinical[The effect of vilon (Lys-Glu) on 1.2-dimethylhydrazine-induced neoplasia]. (2005) · preclinical20012005

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Vilon yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier

    nothing resolved on this rung

  3. Observational evidence · resolved human data at the emerging tier: thin, or contested

    nothing resolved on this rung

  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work
    • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. · pmid 11163623 · 2001
    • [The effect of vilon (Lys-Glu) on 1.2-dimethylhydrazine-induced neoplasia]. · pmid 16308980 · 2005

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.