Research
VIP — living evidence map
The Atlas page holds the claims; this is how its evidence evolved.
Summary
Vasoactive intestinal peptide (VIP) belongs to a superfamily of structurally related peptide hormones that includes glucagon, the glucagon-like peptides, secretin and growth hormone-releasing hormone. · pmid:22289055
Mechanism
It acts through the class B G protein-coupled receptors VPAC1 and VPAC2, which also respond to PACAP, and has roles in circadian rhythm, learning and memory and responses to stress. · pmid:22289055
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Proportion of the 1 claim about VIP standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for VIP yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
- Approved-label dose · a resolved regulatory document names a labelled dose
nothing resolved on this rung
- Studied human doses · resolved human studies at the established tier
- Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. · pmid 22289055 · 2012
- Observational evidence · resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
- Community-reported protocols · protocol propositions from distinct members, counted once per human
nothing resolved on this rung
- Preclinical evidence · resolved animal, cell or mechanistic work
nothing resolved on this rung
1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.