Peptide Atlas · Small molecule

5-Amino-1MQ

5-Amino-1MQ belongs to a series of methylquinolinium small-molecule inhibitors of nicotinamide N-methyltransferase (NNMT), reported to be membrane-permeable and selective against related methyltransferases; it is a small molecule, not a peptide.

preclinical

provisional
2 citations
0 discussions
0 followers
5-amino-1-methylquinolinium
NNMT inhibitor

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for 5-Amino-1MQ. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Methylquinolinium NNMT inhibitors are permeable and selective; one reversed diet-induced obesity in mice	preclinical	pmid 29155147
An NNMT inhibitor activated senescent muscle stem cells and improved regeneration in aged mouse muscle	preclinical	pmid 30753815

Unanswered questions

Has any NNMT inhibitor from this methylquinolinium series been studied in humans? open

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.