5-Amino-1MQ belongs to a series of methylquinolinium small-molecule inhibitors of nicotinamide N-methyltransferase (NNMT), reported to be membrane-permeable and selective against related methyltransferases; it is a small molecule, not a peptide.
preclinical — animal, cell or mechanistic work — not yet about people
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kind set kind set to small_molecule: palette r2 · 2026-09-27 12:04 · somebody
kind set kind set to peptide: palette r1 · 2026-09-27 04:00 · somebody
identity withheld identity not published: PubChem gave no record that proves it is this substance · 2026-09-27 04:00 · somebody
fact added summary: 5-Amino-1MQ belongs to a series of methylquinolinium small-molecule inhibitors of nicotinamide N-methyltransferase (NNMT · 2026-09-27 04:00 · somebody
fact added mechanism: In cultured adipocytes these inhibitors lowered the NNMT product 1-methylnicotinamide, raised intracellular NAD+ and sup · 2026-09-27 04:00 · somebody
created page created as '5-Amino-1MQ' with aliases 5-amino-1-methylquinolinium, NNMT inhibitor · 2026-09-27 04:00 · somebody
citation added pmid 29155147 cited as preclinical: Methylquinolinium NNMT inhibitors are permeable and selective; one reversed diet-induced obesity in · 2026-09-27 04:00 · somebody
citation added pmid 30753815 cited as preclinical: An NNMT inhibitor activated senescent muscle stem cells and improved regeneration in aged mouse musc · 2026-09-27 04:00 · somebody
question added Has any NNMT inhibitor from this methylquinolinium series been studied in humans? · 2026-09-27 04:00 · somebody
fact added mechanism: In 24-month-old mice after an acute muscle injury, an NNMT inhibitor increased muscle stem cell proliferation and fusion · 2026-09-27 04:00 · somebody
Negative findings
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