Peptide Atlas · Small molecule

5-Amino-1MQ

5-Amino-1MQ belongs to a series of methylquinolinium small-molecule inhibitors of nicotinamide N-methyltransferase (NNMT), reported to be membrane-permeable and selective against related methyltransferases; it is a small molecule, not a peptide.

preclinical

provisional
2 citations
0 discussions
0 followers
5-amino-1-methylquinolinium
NNMT inhibitor

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Methylquinolinium NNMT inhibitors are permeable and selective; one reversed diet-induced obesity in mice standing
- resolved
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.
Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ
pmid 29155147
- preclinical
  Claim: An NNMT inhibitor activated senescent muscle stem cells and improved regeneration in aged mouse muscle standing
- resolved
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.
Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ
pmid 30753815

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Negative findings

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