Peptide Atlas · Peptide

ACE-031

ACE-031 is a fusion protein of the activin receptor type IIB and an IgG1 Fc domain that binds myostatin and related ligands that restrain muscle growth.

emerging

provisional
2 citations
0 discussions
0 followers
ACVR2B-Fc
Activin Receptor Type IIB-Fc
Ramatercept

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Single ascending-dose study in healthy volunteers: increases in lean mass and thigh muscle volume standing
- resolved
A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers.
Attie KM, Borgstein NG, Yang Y, Condon CH, Wilson DM, Pearsall AE, Kumar R, Willins DA, Seehra JS, Sherman ML
pmid 23169607
- emerging
  Claim: Randomized trial in Duchenne muscular dystrophy stopped over epistaxis and telangiectasias standing
- resolved
Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial.
Campbell C, McMillan HJ, Mah JK, Tarnopolsky M, Selby K, McClure T, Wilson DM, Sherman ML, Escolar D, Attie KM
pmid 27462804

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.