Peptide Atlas · Protein

ACE-083

ACE-083 is a locally acting, follistatin-based therapeutic protein that binds myostatin and other regulators of muscle; in a first-in-human study, injections into a single leg muscle of healthy postmenopausal women increased that muscle's volume by up to 14.5% without changing mean muscle strength.

emerging

provisional
2 citations
0 discussions
0 followers
FST(modified)-IgG2 Fc fusion
locally-acting follistatin trap
modified follistatin-Fc

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for ACE-083. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Locally injected ACE-083 increased targeted muscle volume in healthy volunteers without a mean strength change	emerging	pmid 29486514
ACE-083 increased muscle volume in FSHD without consistent functional improvement	emerging	pmid 35428982

Unanswered questions

Has any study of ACE-083 shown a functional benefit, not only a gain in muscle volume? open

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.