Peptide Atlas · Protein

ACE-083

ACE-083 is a locally acting, follistatin-based therapeutic protein that binds myostatin and other regulators of muscle; in a first-in-human study, injections into a single leg muscle of healthy postmenopausal women increased that muscle's volume by up to 14.5% without changing mean muscle strength.

emerging

provisional
2 citations
0 discussions
0 followers
FST(modified)-IgG2 Fc fusion
locally-acting follistatin trap
modified follistatin-Fc

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Locally injected ACE-083 increased targeted muscle volume in healthy volunteers without a mean strength change standing
- resolved
Locally acting ACE-083 increases muscle volume in healthy volunteers.
Glasser CE, Gartner MR, Wilson D, Miller B, Sherman ML, Attie KM
pmid 29486514
- emerging
  Claim: ACE-083 increased muscle volume in FSHD without consistent functional improvement standing
- resolved
Randomized phase 2 study of ACE-083, a muscle-promoting agent, in facioscapulohumeral muscular dystrophy.
Statland JM, Campbell C, Desai U, Karam C, Díaz-Manera J, Guptill JT, Korngut L, Genge A, Tawil RN, Elman L, Joyce NC, Wagner KR, Manousakis G, Amato AA, Butterfield RJ, Shieh PB, Wicklund M, Gamez J, Bodkin C, Pestronk A, Weihl CC, Vilchez-Padilla JJ, Johnson NE, Mathews KD, Miller B, Leneus A, Fowler M, van de Rijn M, Attie KM
pmid 35428982

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Negative findings

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