PepJunkie Home of the Peptonauts
More

Peptide Atlas · Small molecule

Acetyl-L-Carnitine (ALCAR)

A meta-analysis of double-blind, placebo-controlled trials lasting 3 to 12 months in mild cognitive impairment and mild Alzheimer's disease found a small advantage for acetyl-L-carnitine over placebo on clinical and psychometric measures.

What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • emerging
      Claim: Meta-analysis: small effect of acetyl-L-carnitine over placebo in MCI and mild Alzheimer's disease standing
    • resolved

    Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease.

    Montgomery SA, Thal LJ, Amrein R

    pmid 12598816

    • emerging
      Claim: Acetyl-L-carnitine increased taxane-induced neuropathy at 24 weeks in a placebo-controlled trial standing
    • resolved

    Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy.

    Hershman DL, Unger JM, Crew KD, Minasian LM, Awad D, Moinpour CM, Hansen L, Lew DL, Greenlee H, Fehrenbacher L, Wade JL, Wong SF, Hortobagyi GN, Meyskens FL, Albain KS

    pmid 23733756

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.