Peptide Atlas · Small molecule

Alpha-lipoic acid

Alpha-lipoic acid (thioctic acid) is an antioxidant; in the 3-week ALADIN trial in 328 people with type 2 diabetes and painful neuropathy, daily intravenous infusions of 600 or 1,200 mg reduced foot symptom scores more than placebo.

established

provisional
PubChem 864
2 citations
0 discussions
0 followers
5-(1,2-dithiolan-3-yl)pentanoic acid
ALA
R-ALA (R-enantiomer)
lipoic acid
sodium R-lipoate (sodium salt)
thioctic acid

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'Alpha-lipoic acid' with aliases ALA, thioctic acid, lipoic acid, 5-(1,2-dithiolan-3-yl)pentanoic acid, R-ALA (R-enantiomer), sodium R-lipoate (sodium salt) · 2026-09-27 12:04 · somebody
kind set kind set to small_molecule: palette r2 · 2026-09-27 12:04 · somebody
fact added identity: PubChem CID 864: alpha Lipoic acid, C8H14O2S2, 206.3 g/mol. · 2026-09-27 12:04 · somebody
fact added identity: CAS registry number 1077-28-7. · 2026-09-27 12:04 · somebody
fact added identity: IUPAC name: 5-(dithiolan-3-yl)pentanoic acid. · 2026-09-27 12:04 · somebody
fact added summary: Alpha-lipoic acid (thioctic acid) is an antioxidant; in the 3-week ALADIN trial in 328 people with type 2 diabetes and p · 2026-09-27 12:04 · somebody
fact added summary: A meta-analysis of four placebo-controlled trials (1,258 patients) found that three weeks of daily intravenous alpha-lip · 2026-09-27 12:04 · somebody
citation added pmid 8786016 cited as emerging: Intravenous alpha-lipoic acid reduced symptoms of diabetic neuropathy over 3 weeks (ALADIN) · 2026-09-27 12:04 · somebody
citation added pmid 14984445 cited as established: Meta-analysis of four RCTs: intravenous alpha-lipoic acid improves symptomatic diabetic polyneuropat · 2026-09-27 12:04 · somebody

Negative findings

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