Peptide Atlas · Small molecule

Alpha-lipoic acid

Alpha-lipoic acid (thioctic acid) is an antioxidant; in the 3-week ALADIN trial in 328 people with type 2 diabetes and painful neuropathy, daily intravenous infusions of 600 or 1,200 mg reduced foot symptom scores more than placebo.

established

provisional
PubChem 864
2 citations
0 discussions
0 followers
5-(1,2-dithiolan-3-yl)pentanoic acid
ALA
R-ALA (R-enantiomer)
lipoic acid
sodium R-lipoate (sodium salt)
thioctic acid

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Intravenous alpha-lipoic acid reduced symptoms of diabetic neuropathy over 3 weeks (ALADIN) standing
- resolved
Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study).
Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schütte K, Gries FA
pmid 8786016
- established
  Claim: Meta-analysis of four RCTs: intravenous alpha-lipoic acid improves symptomatic diabetic polyneuropathy standing
- resolved
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis.
Ziegler D, Nowak H, Kempler P, Vargha P, Low PA
pmid 14984445

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Negative findings

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