Citrate buffer is common in subcutaneous biologics; in a systematic review, five of seven direct comparisons reported less injection-site pain with citrate-free formulations.
established — replicated in humans, or settled by a regulator
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created page created as 'Citrate buffer' · 2026-09-27 04:00 · somebody
kind set kind set to buffer: palette r1 · 2026-09-27 04:00 · somebody
identity withheld identity not published: a buffer is a system of components, not one compound · 2026-09-27 04:00 · somebody
fact added summary: Citrate buffer is common in subcutaneous biologics; in a systematic review, five of seven direct comparisons reported le · 2026-09-27 04:00 · somebody
fact added history: Buffers can influence perceived pain on injection, a safety consideration discussed alongside their stabilizing roles. · 2026-09-27 04:00 · somebody
citation added pmid 36043729 cited as emerging: Systematic review: citrate and injection-site pain · 2026-09-27 04:00 · somebody
citation added pmid 27894967 cited as established: Review: role of buffers in protein formulations · 2026-09-27 04:00 · somebody
link added component: pje_citric-acid · 2026-09-27 04:00 · somebody
link added component: pje_sodium-citrate-tribasic · 2026-09-27 04:00 · somebody
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