Peptide Atlas · Other substance

Cortexin

In a Russian multicenter randomized study in 189 patients with chronic cerebral ischemia, intramuscular cortexin reduced neurological symptoms, asthenia and sleep disturbance in a dose-dependent way compared with basic treatment alone.

emerging

provisional
3 citations
0 discussions
1 follower
bovine/porcine cortex peptide extract
cerebral cortex polypeptides
cortexin polypeptide complex

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What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Cortexin. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Cortexin in chronic cerebral ischemia (Russian multicenter RCT, n=189)	emerging	pmid 30335070
Review (Russian): composition and proposed targets of cortexin	preclinical	pmid 26356623
Cortexin, Cerebrolysin and Actovegin in rat brain ischemia models	preclinical	pmid 34260655

Unanswered questions

The name cortexin is also used for an unrelated neuronal membrane protein; which peer-reviewed studies of the drug have been replicated outside Russia? open

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.