Peptide Atlas · Excipient

D-Mannitol

Mannitol is a crystallizing bulking agent in freeze-drying: with 4% mannitol and 1% sucrose, a cake of crystalline mannitol and amorphous sucrose allowed primary drying at -10 C where sucrose alone would have needed below -35 C.

established

provisional
PubChem 6251
2 citations
0 discussions
0 followers
D-Mannitol (anhydrous)
Mannitol

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for D-Mannitol. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Mannitol-sucrose mixtures for protein lyophilization	established	pmid 11948529
Factors in mannitol hemihydrate formation	preclinical	pmid 24239581

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.