Peptide Atlas · Excipient

D-Mannitol

Mannitol is a crystallizing bulking agent in freeze-drying: with 4% mannitol and 1% sucrose, a cake of crystalline mannitol and amorphous sucrose allowed primary drying at -10 C where sucrose alone would have needed below -35 C.

established

provisional
PubChem 6251
2 citations
0 discussions
0 followers
D-Mannitol (anhydrous)
Mannitol

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Mannitol-sucrose mixtures for protein lyophilization standing
- resolved
Mannitol-sucrose mixtures--versatile formulations for protein lyophilization.
Johnson RE, Kirchhoff CF, Gaud HT
pmid 11948529
- preclinical
  Claim: Factors in mannitol hemihydrate formation standing
- resolved
Formation of mannitol hemihydrate in freeze-dried protein formulations--a design of experiment approach.
Larsen HM, Trnka H, Grohganz H
pmid 24239581

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

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