DNSP-11 (dopamine neuron stimulating peptide-11) is an 11-amino-acid amidated peptide proposed to arise from the proregion of the human GDNF precursor; a single dose into the rat substantia nigra increased potassium-evoked dopamine release in parts of the striatum two weeks later.
preclinical — animal, cell or mechanistic work — not yet about people
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created page created as 'DNSP-11' with aliases Dopamine Neuron Stimulating Peptide-11 · 2026-09-27 12:04 · somebody
kind set kind set to peptide: palette r2 · 2026-09-27 12:04 · somebody
identity withheld identity not published: PubChem gave no record that proves it is this substance · 2026-09-27 12:04 · somebody
fact added summary: DNSP-11 (dopamine neuron stimulating peptide-11) is an 11-amino-acid amidated peptide proposed to arise from the proregi · 2026-09-27 12:04 · somebody
fact added summary: Given intranasally for three weeks to rats, DNSP-11 increased dopamine turnover and, in a 6-hydroxydopamine model of Par · 2026-09-27 12:04 · somebody
citation added pmid 24406899 cited as preclinical: DNSP-11 changes dopamine neuron function in rats and phosphorylates ERK1/2 in vitro · 2026-09-27 12:04 · somebody
citation added pmid 25999268 cited as preclinical: Repeated intranasal DNSP-11 in normal and 6-OHDA-lesioned rats · 2026-09-27 12:04 · somebody
Negative findings
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