Peptide Atlas · Peptide

DNSP-11

DNSP-11 (dopamine neuron stimulating peptide-11) is an 11-amino-acid amidated peptide proposed to arise from the proregion of the human GDNF precursor; a single dose into the rat substantia nigra increased potassium-evoked dopamine release in parts of the striatum two weeks later.

preclinical

provisional
2 citations
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Dopamine Neuron Stimulating Peptide-11

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: DNSP-11 changes dopamine neuron function in rats and phosphorylates ERK1/2 in vitro standing
- resolved
Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro.
Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH, Cass WA, Gash DM, Gerhardt GA
pmid 24406899
- preclinical
  Claim: Repeated intranasal DNSP-11 in normal and 6-OHDA-lesioned rats standing
- resolved
Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.
Stenslik MJ, Potts LF, Sonne JW, Cass WA, Turchan-Cholewo J, Pomerleau F, Huettl P, Ai Y, Gash DM, Gerhardt GA, Bradley LH
pmid 25999268

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