Epitalon (Epithalon) is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), synthesized on the basis of the amino acid composition of epithalamin, a bovine pineal gland extract.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Epitalon (Epithalon) is the tetrapeptide Ala-Glu-Asp-Gly (AEDG), synthesized on the basis of the amino acid composition of epithalamin, a bovine pineal gland extract. · pmid:40141333
Mechanism
Added to telomerase-negative human fetal fibroblasts, it induced expression of the telomerase catalytic subunit, telomerase activity and telomere elongation. · pmid:12937682
History
Given monthly to female CBA mice from six months of age until natural death, the tetrapeptide increased mean survival by 5.3% and lowered spontaneous tumour incidence. · pmid:11163623
A 2025 review notes that physico-chemical and structural studies of the peptide remain limited and that it is uncertain whether its reported mechanisms are its only ones. · pmid:40141333
Proportion of the 3 claims about Epitalon standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Epitalon yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. · pmid 11163623 · 2001
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. · pmid 12937682 · 2003
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. · pmid 40141333 · 2025
3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.