Follistatin binds myostatin, the most powerful inhibitor of muscle growth yet characterized, with high affinity and blocks its inhibition of muscle development.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
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emerging
Claim: Phase 1/2a AAV1.FS344 gene therapy in Becker muscular dystrophystanding
resolved
A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy.
Mendell JR, Sahenk Z, Malik V, Gomez AM, Flanigan KM, Lowes LP, Alfano LN, Berry K, Meadows E, Lewis S, Braun L, Shontz K, Rouhana M, Clark KR, Rosales XQ, Al-Zaidy S, Govoni A, Rodino-Klapac LR, Hogan MJ, Kaspar BK
A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.
Negative findings
failure is information
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