Follistatin binds myostatin, the most powerful inhibitor of muscle growth yet characterized, with high affinity and blocks its inhibition of muscle development.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Follistatin binds myostatin, the most powerful inhibitor of muscle growth yet characterized, with high affinity and blocks its inhibition of muscle development. · pmid:15136138
History
A phase 1/2a gene therapy trial in Becker muscular dystrophy delivered the alternatively spliced FS344 isoform by viral vector into the quadriceps of six patients; four walked further on the six-minute walk test and no adverse effects were encountered. · pmid:25322757
Identity
No public registry record is shown for this page: PubChem gave no record that proves it is this substance.
Where the evidence actually sits
Emerging50%
Preclinical only50%
Proportion of the 2 claims about Follistatin-344 standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Follistatin-344 yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy. · pmid 25322757 · 2015
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis. · pmid 15136138 · 2004
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.