Glutathione disulfide (GSSG, oxidized glutathione)

Summary

Glutathione disulfide (GSSG) is the oxidized form of glutathione; the GSSG/glutathione couple is the most abundant redox couple in a cell and serves as an indicator of its redox environment. · pmid:11368918

Mechanism

The half-cell reduction potential of the GSSG/glutathione couple has been estimated at about -240 mV in proliferating cells, -200 mV in differentiating cells and -170 mV in cells undergoing apoptosis. · pmid:11368918

Identity

PubChem CID 65359: Glutathione Disulfide, C20H32N6O12S2, 612.6 g/mol. · pubchem:65359

CAS registry number 27025-41-8. · pubchem:65359

IUPAC name: (2S)-2-amino-5-[[(2R)-3-[[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. · pubchem:65359

Where the evidence actually sits

Proportion of the 1 claim about Glutathione disulfide (GSSG, oxidized glutathione) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

1 resolved citation, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Glutathione disulfide (GSSG, oxidized glutathione) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. · pmid 11368918 · 2001
3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

1 resolved citation, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.