preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Histidine buffers are widely used in freeze-dried monoclonal antibody formulations, often as histidine-HCl. · pmid:41308842
Mechanism
Under fluorescent light, histidine-derived photosensitizers accumulate in the buffer and mediate oxidation of a formulated antibody; the effect was reduced at pH above 7 or without oxygen. · pmid:21786276
Identity
No public registry record is shown for this page: a buffer is a system of components, not one compound.
Where the evidence actually sits
Preclinical only100%
Proportion of the 2 claims about Histidine buffer standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Histidine buffer yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Photosensitizers form in histidine buffer and mediate the photodegradation of a monoclonal antibody. · pmid 21786276 · 2011
A novel histidine-acetate buffer for freeze-dried monoclonal antibody formulations. · pmid 41308842 · 2026
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.