Hydrochloride is, with acetate, the salt form in which the great majority of therapeutic peptides are marketed; trifluoroacetate salts are viewed less favourably by medicine regulators.
fact added summary: Hydrochloride is, with acetate, the salt form in which the great majority of therapeutic peptides are marketed; trifluor · 2026-09-27 04:00 · somebody
fact added history: Trifluoroacetate counterions are commonly exchanged for chloride by freeze-drying the peptide from hydrochloric acid. · 2026-09-27 04:00 · somebody
citation added pmid 40365687 cited as established: Hydrochloride and acetate as marketed peptide salt forms · 2026-09-27 04:00 · somebody
citation added pmid 40872554 cited as preclinical: Exchange of TFA for chloride · 2026-09-27 04:00 · somebody
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