Peptide Atlas · Salt form

Hydrochloride salt

Hydrochloride is, with acetate, the salt form in which the great majority of therapeutic peptides are marketed; trifluoroacetate salts are viewed less favourably by medicine regulators.

established

provisional
PubChem 313
2 citations
0 discussions
0 followers
HCl salt

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Hydrochloride and acetate as marketed peptide salt forms standing
- resolved
Impact of counterion and salt form on the properties of long-acting injectable peptide hydrogels for drug delivery.
Moore JV, Cross ER, An Y, Pentlavalli S, Coulter SM, Sun H, Laverty G
pmid 40365687
- preclinical
  Claim: Exchange of TFA for chloride standing
- resolved
Towards a Consensus for the Analysis and Exchange of TFA as a Counterion in Synthetic Peptides and Its Influence on Membrane Permeation.
Erckes V, Streuli A, Chamera Rendueles L, Krämer SD, Steuer C
pmid 40872554

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.